Outreach Programs

Education Programs Technology Outreach Program International Programs Distinguished Lecturer Series International Center for Materials Research MRL Diversity Fellowship MRL Travel Fellowship

Intern: Stephanie Kern, Forensic Chemistry, Lake Superior State University Mentor: Chosu Khin Faculty Supervisor: Peter C. Ford Department: Chemistry and Biochemistry Department

STUDY OF THE NITROSYLATION PATHWAYS OF COPPER(II) CYCLAM DERIVATIVES

Nitric Oxide (NO) interactions with metal-centered heme proteins play an important role in the bioregulation functions. In humans, NO is associated with vasodilation, neurotransmission, immune response and a number of diseases that have been associated with over and/or under production of NO. Reductive nitrosylation is one reaction pathway for NO interaction with metal centers. During reductive nitrosylation reaction, reduction of metal center by NO takes place and nitrosylated products result. In this research, Cu(II) cyclam derivatives with different molecular groups, such as chromophores, are used to study their interactions with NO in light for the development of fluorescence based NO sensor. Kinetic and mechanistic aspects of these Cu(II) cyclam complexes will be further explored.

Return to the RISE 2005 project list