The innovation engine for new materials

Waters UPLC-MS

Achieve stunning separations and accurate masses with the Waters Acquity H-class Ultra High Pressure Liquid Chromatography (UPLC) system coupled with a Waters Xevo G2-XS Time-of-Flight Mass Spectrometer. With an electrospray ionization (ESI) source, the ToF MS can provide mass data up to 100,000 m/z either operating with the UPLC or independently, and signals can be optimized by operating in resolution or sensitivity mode. Whether you want to resolve the parent ion or its fragments, using increased collision energy, both results can be collected, providing your desired quantitative or qualitative results. High resolution (10 ppm or less) can also be acheived with a special calibration.


Pump: Waters Acquity H-class Quaternary Separations Module.
Chilled Autosampler Compartment
Columns available: Waters BEH C18 and C4
Solvents: MilliQ Water with 0.1% Formic Acid, Acetonitrile with 0.1% Formic Acid, other MS grade solvents available
Flow Rate: 0.5 mL/min
Injection: 5 μL
Detectors: Waters Tunable UV detector, Xevo G2-XS Tof MS
MS sources: ESI or ASAP
Software: MassLynx



MRL room 1051

Manufacturer's Info: 

Instrument Information and/or Manual: 

PDF icon UPLC-MS_2022.pdf135.69 KB


Please contact Dr. Rachel Behrens (rachel [at] mrl [dot] ucsb [dot] edu) to schedule training. Before training starts please read the MANUAL and the Waters Mass Spectrometry Primer: