Developing drug delivery systems that are modular in their design and allows for the accommodation of different types of chemotherapeutics is highly relevant in drug discovery research. For injectable drug carriers, benefits such as improved bioavailability, biodistribution and pharmacokinetic properties have been proven with polymer based nanomedicines. One area of nanomedicine that is growing in importance is nanosafety and the requirements on the nanoscale delivery agents. Ideally these systems should be non‐toxic, degradable and non‐immunogenic, which is why degradable polyesters and poly(ethylene glycols) are highly suitable. Our work is centered on utilizing dendritic polymers, (dendrimers, hyperbranched polymers and linear‐dendritic structures) based on the bis‐MPA monomer unit as theranostic nanosystems for breast cancer therapy and imaging via 19F‐MRI. Our recent work has clearly proven the non‐toxic nature of these materials in cancer cell lines and in suitable models for injectable drug carriers such as human macrophages. In this work we will show how we design modular carrier systems for chemotherapeutics, investigate their physiochemical properties and finally evaluate them in vitro and in human primary cells.
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