The innovation engine for new materials

Dendrimers and Linear Dendritic Hybrids as Theranostic Carriers for Combinded MRI and Cancer Therapy

Seminar Group: 


Assoc. Prof. Andreas M. Nyström


Swedish Medical Nanoscience Center, Karolinska Insitutet
Stockholm, Sweden


Friday, February 3, 2012 - 11:00am


MRL Room 2053

Developing drug delivery systems that are modular in their design and allows for the accommodation of different types of chemotherapeutics is highly relevant in drug discovery research. For injectable drug carriers, benefits such as improved bioavailability, biodistribution and pharmacokinetic properties have been proven with polymer based nanomedicines. One area of nanomedicine that is growing in importance is nanosafety and the requirements on the nanoscale delivery agents. Ideally these systems should be non‐toxic, degradable and non‐immunogenic, which is why degradable polyesters and poly(ethylene glycols) are highly suitable. Our work is centered on utilizing dendritic polymers, (dendrimers, hyperbranched polymers and linear‐dendritic structures) based on the bis‐MPA monomer unit as theranostic nanosystems for breast cancer therapy and imaging via 19F‐MRI. Our recent work has clearly proven the non‐toxic nature of these materials in cancer cell lines and in suitable models for injectable drug carriers such as human macrophages. In this work we will show how we design modular carrier systems for chemotherapeutics, investigate their physiochemical properties and finally evaluate them in vitro and in human primary cells.

1. Andreas M. Nyström, and Bengt Fadeel, “Safety assessment of nanomaterials: implications for nanomedicine”, accepted for publication in Journal of Controlled Release 2012. 2. Karen L. Wooley, and Andreas M Nyström, “The importance of chemistry in creating well‐defined nanoscopic embedded therapeutics: Devices capable of the dual functions of imaging and therapy”, Accounts of Chemical Research, 2011, 44, 969‐978. Pubmed id: 21675721, No of citations: 1. 3. Neus Feliu, Marie Walter, Maria Montanez, Anders Hult, Andreas Nyström, Michael Malkoch, and Bengt Fadeel, “Stability and biocompatibility of a library of polyester dendrimers in comparison to polyamidoamine dendrimers.” Biomaterials 2012 Mar;33(7):1970‐1981. PMID: 22177621. 4. Xianghui Zeng, Yuning Zhang, Zhihua Wu, Pontus Lundberg, Michael Malkoch, and Andreas M. Nyström “Hyperbranched copolymer micelles as delivery vehicles of doxorubicin in breast cancer cells”, Journal of Polymer Science Part A: Polymer Chemistry, 2012, 50, 280‐288. 6. Andreas M. Nyström, Jeremy Bartels, Wenjun Du, and Karen L. Wooley, “Perfluorocarbon‐loaded Shell Crosslinked Knedel‐like Nanoparticles: Lessons regarding polymer mobility and self assembly”, Journal of Polymer Science Part A: Polymer Chemistry 2009, 47, 1023‐1037. PUBMED: 20157345. Also featured on the cover of the issue. No of citations: 18.